Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Early life cold and heat exposure impacts white matter development in children
Brain scans of more than 2500 preadolescents suggest that early life exposure to heat and cold may have lasting impacts on brain white matter. The study, published in Nature Climate Change, highlights the vulnerability of foetuses and children to extreme temperatures
Targeting fatty acid synthase in preclinical models of triple-negative breast cancer brain metastases synergizes with chemotherapy and impairs invasion
Metastatic triple-negative breast cancer cells need to acquire the ability to produce new fatty acids to more effectively colonize the brain. Our study investigates how this metabolic vulnerability can be targeted to increase efficacy of chemotherapies and impair cancer cell invasion.
Automated assessment of cardiac dynamics in aging and dilated cardiomyopathy Drosophila models using machine learning
Our platform uses deep learning to segment optical microscopy images of Drosophila hearts, facilitating the quantification of cardiac parameters for aging and dilated cardiomyopathy. Moreover, using a machine learning approach we able to predict cardiac aging with high accuracy.
Exploring SHANK3 in Neurodevelopment Using Stem Cells and Chemical Biology
Here we delve into our research on Phelan-McDermid syndrome (PMDS), a rare genetic disorder. We focused on SHANK3, an integral protein in neurodevelopment and synaptic function. We explore potential treatment strategies for PMDS, aiming to contribute to drug discovery in neurodevelopmental diseases.
