Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Nontuberculous Mycobacterial Infection and Environmental Molybdenum in Persons with Cystic Fibrosis: A Case-Control Study in Colorado
NTM are ubiquitous environmental bacteria that may cause chronic lung disease and are one of the most difficult to treat infections among persons with cystic fibrosis (pwCF). We identified molybdenum in the source water as the most predictive factor of M. abscessus infection among pwCF in Colorado.
An in situ activity assay for lysyl oxidases
Current methods for detecting activity of lysyl oxidases lack specificity and do not provide information on how much activity is occurring in situ. Hydrazide reagents can be used to measure their in situ activity levels in a practicable, sensitive, and specific manner.
Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
Our study demonstrates that tertiary lymphoid structures (TLS) can form in human glioma, and that agonistic CD40 therapy (αCD40) promotes the formation of TLS in murine glioma models. However, αCD40 also impairs T cell function through the induction of regulatory B cells in the tumor.
Error tolerant barcodes for single-cell sequencing
Synthesising oligonucleotides using blocks of nucleotides to overcome sequencing errors in error prone single-cell RNA-sequencing.
