Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
How many bird and mammal extinctions has recent conservation action prevented?
We hear much about the worsening status of species, and in particular, that increasing numbers of species face extinction. Indeed, the landmark Global Assessment from the Intergovernmental Platform on Biodiversity and Ecosystem Services reported that 1 million species may be at risk of extinction.
After the Paper: Unravelling the role of TLR4 in mediating the human dendritic cell activation by filaria
Identification of Toll-like receptor 4 (TLR4) as the crucial regulator of inflammation in human lymphatic filariasis has provoked the conception of TLR-directed therapy against filariasis.
A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent anti-tumor response
The type 1 NKT cell stimulating glycolipid α-galactosylceramide (α-GalCer) was first identified by the Pharmaceutical Research Laboratory of Kirin Brewery in a screen for novel anti-tumor agents. Based on promising preclinical data it was tested as an anticancer drug in multiple clinical studies.
New players against AML: novel targets with preclinical potencies
Better understanding of AML biology and survival tactics has facilitated a wave of newly approved drugs against AML and also revealed a range of targets to be exploited for treatment. In our review, we discuss what these new targets are and how targeting them in combination might be beneficial.
The story behind the SAVI project
A computer-generated database of a billion+ easily synthesizable molecules aimed at drug design
