Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
cfDNA dynamics decipher mechanism of action of Ibrutinib in patients with MCL
We investigated cfDNA dynamics prior to and during induction treatment of patients with MCL treated within the TRIANGLE trial and showed an early and superior disease clearance when treated with Ibrutinib and hints toward improved disease clearance in lymph nodes than using chemotherapy
The architectonics of cancer tissue: a “bulk” analytical framework to study cancer tissue organization
Solid tumors are diagnosed by histopathology, which recognizes abnormal tissue architecture. We asked whether these changes are random or follow recurring rules. Using large-scale bulk RNA-seq, we derived quantitative “architecture” signatures that stratify cancers and link to prognosis.
Dynamics of Machines and Hydraulic Systems. Mechanical Vibrations and Pressure Pulsations
- Describes practical sources of vibration acting on hydraulic system components
- It combines the elements of vibration and dynamic phenomena in hydraulic systems in an unprecedented way
- Demonstrates the impact of non-stationary flow on the energy efficiency of hydraulic systems
Anasakti in VUCA World
This paper explores Anasakti (non-attachment) as a guiding principle for navigating the VUCA world—marked by volatility, uncertainty, complexity, and ambiguity. It emphasizes inner stability, mindful detachment, and ethical resilience as pathways to effective leadership and decision-making.
From uncertainty to stability: a case of cultural integration of two organisations
Cultural integration during mergers is complex in today’s volatile global environment. This case study of Indian consultancy Kognitivus outlines a three-phase model—stability, uniformity, sustainability—to guide integration across divergent organisational maturity levels.
Exploring the Buurtzorg model : A paradigm shift in global homecare
This research paper examines Buurtzorg Nederland’s self-managed homecare model, emphasizing humanity over bureaucracy. It analyzes how autonomy, trust, and intrinsic motivation enhance performance and explores the model’s applicability and sustainability within India’s healthcare context.