Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Bioengineering & Biotechnology
Neoantigen Vaccine Nanoformulations based on Chemically Synthesized Minimal mRNA (CmRNA): Small Molecules, Big Impact
Our npj Vaccines article unveils a prospective breakthrough in personalized cancer immunotherapy, featuring Chemically Synthesized Minimal mRNA (CmRNA) in Lipid-Polymer Hybrid Nanoparticles (LPPs). This idea not only answers ongoing research needs but propels a paradigm shift in cancer treatment.
UBS-seq: An ultrafast bisulfite sequencing method more accurately detecting 5-methylcytosine in DNA and RNA
Current bisulfite sequencing (BS-seq) suffers from notable limitations such as long reaction time, severe DNA damage, overestimation of modification level etc. UBS-seq overcomes these limitations and detects 5-methylcytosine in DNA and RNA accurately starting from low input biological samples.
The Grinch got big for us with no physical consequences. But how do we prevent aneurysms from rupturing in real life?
They say that the Grinch’s heart grew three sizes in one day. In the land of fantasy, this makes him a happier person and a friendlier neighbor to the Whos. In real life, rapid cardiovascular expansion is a silent but deadly disease.
Quadrivalent self-amplifying mRNA vaccines generate protective antibody and cell-mediated immunity to influenza
Self-amplifying mRNA is a promising platform for vaccine development, highlighted by our group's recent publication in npj Vaccines showing that a quadrivalent bicistronic sa-mRNA vaccine can generate protective immunity to both HA and NA from 4 influenza strains when formulated in a single vaccine.
