Plasminogen-Apple-Nematode (PAN) domain: A new target to modulate the HGF/c-MET signaling in cancers.
Our newly published paper suggests that four cysteine residues at the core of the HGF PAN domain are essential for its binding with the proto-oncogenic receptor c-MET and the subsequent activation of the downstream signaling cascade. Debjani Pal, Kuntal De, and Wellington Muchero.
Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway
We used molecular, genetic and bioinformatic approaches to determine the mechanism of micronuclei formation induced by two TOP1 poisons (CPT and LMP776) in different human cancer cells, including SCLC cell lines.
The challenges of neoadjuvant trials, what we learnt from NAXIVA
NAXIVA is the first clinical trial to evaluate neoadjuvant downstaging of patients with the unique biological phenomenon of venous tumour thrombus in kidney cancer. But what did we learn beyond the endpoints?
