Rapid acceleration of pancreatic adenocarcinoma development by PPARĪ“ hyperactivation
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with a rising incidence in the United States and globally. Effective strategies to prevent and treat PDAC are urgently needed. The majority of PDACs arise from pancreatic intraepithelial neoplasia (PanIN) pre-cancerous lesions.
GIPC2 interacts with Fzd7 to promote prostate cancer metastasis by activating WNT signaling
GIPC2, a novel exosomal molecule, associated with WNT signaling as a potential therapeutic target, is a putative unique epigenetic oncogene in the prostate cancer metastasis.