Active Autophagy May Be Good for Survivals of Cancer Patients
Mutants in LRPPRC gene was found to be associated with French Canadian Type Leigh syndrome. Here we used a mouse model to confirm that LRPPRC acted through P62 and HDAC6 to activate autophagy and through Yap and P27 to maintain genome stability so that hepatocellular carcinoma was suppressed.
PBRM1: A Potential Negative Predictive Biomarker for immunotherapy in NSCLC
In our research, PBRM1 mutation was found to be a negative predictive biomarker of immunotherapy efficacy in NSCLC. Patients with PBRM1 mutation got less survival benefit from immunotherapy for NSCLC.
Targeting dysfunction of microRNA in MLL leukemia
In our latest manuscript in Leukemia, we describe a putative additional mechanism for MYC deregulation downstream of MLL. We further demonstrate that IRAK1/4 inhibitor might improve the efficacy of BET inhibitor through synergistically downregulating MYC in MLL leukemias.
