Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Structural and functional insights underlying recognition of histidine phosphotransfer protein in fungal phosphorelay systems
Phosphorelay systems found in fungi contain several hybrid histidine kinases that transfer phosphoryl groups to the same His-phosphotransferase. This many-to-one mechanism is promoted through a low affinity for interaction and a transient phosphorylation.
Modeling the Growth and Size Distribution of Human Pluripotent Stem Cell Clusters in Culture
Culturing stem cells for clinical applications requires standardized protocols. Bench-scale experiments with hPSCs result in growth of cell clusters under various culture conditions. Mathematical models of cluster size distributions can help to identify plausible growth laws.
Quantifying Cell-State Densities in Single-Cell Phenotypic Landscapes Using Mellon
What constitutes a tissue based on single-cell data and how can we represent it computationally? This question led us to develop Mellon, a tool to quantify cell-state densities and reveal dynamics of cell-differentiation processes. Here's a behind-the-scenes look at our journey.
Mycofluidics of clocks in single filaments of Neurospora crassa
We show single filaments in the model system Neurospora crassa have a biological clock. We also develop model of the clock in single filaments that is supported by microfluidics data and provides an explanation for long distance (mm) synchronization of clocks in filaments.
Exploring SHANK3 in Neurodevelopment Using Stem Cells and Chemical Biology
Here we delve into our research on Phelan-McDermid syndrome (PMDS), a rare genetic disorder. We focused on SHANK3, an integral protein in neurodevelopment and synaptic function. We explore potential treatment strategies for PMDS, aiming to contribute to drug discovery in neurodevelopmental diseases.
