Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Protocols & Methods
Decoding sex-specific metabolomic biomarkers in the loggerhead sea turtle (Caretta caretta)
Is there a distinct metabolomic profile between male and female loggerhead turtles? Are there useful biomarkers for sex classification in this species?
Unveiling the Mechanisms Behind Cancer Aggressiveness: How Epichaperomes Drive Cellular Plasticity
What makes cancer so aggressive and adaptable? Our latest research uncovers a hidden mechanism within cells—specialized protein networks called epichaperomes. These structures help cancer cells survive and thrive, reactivating developmental pathways and fueling unchecked growth.
Mutations may offer clues to cancer development in systemic sclerosis
The latest paper from Natalie Saini's group explores an intriguing connection between inflammation, DNA damage, and cancer via accrual of somatic mutations in patients of systemic sclerosis (scleroderma).
Amphiphilic peptide Mastoparan-B induces conformational changes within the AdeB efflux pump, down-regulates adeB gene expression, and restores antibiotic susceptibility in an MDR strain of Acinetobacter baumannii
A series of computer-based experiments was done to find the mechanism antiefflux activity of MP-B against the MDR strain of A. baumannii (AB). We generated 20 poses of apo-MP-B using the InterPep tool. Analysis revealed that apo MP-B formed H-bonds to the backbone of five amino acids in Helix-5.
Benchmarking algorithms for single-cell multi-omics prediction and integration
totalVI and scArches excelled in predicting protein abundance, while LS_Lab led in predicting chromatin accessibility. Seurat, MOJITOO, and scAI performed best in vertical integration, whereas totalVI and UINMF were superior in horizontal and mosaic integration.
Behind the paper: Untangling Zebrafish Genetic Annotation of TCOF1 and NOLC1
Our research journey began with an intriguing paradox: two genes, TCOF1 and NOLC1, critical for ribosomal RNA processing and nucleolar function, were confusingly annotated in zebrafish databases....
