Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
How I discovered your fingertips could detect cancer!
This invited blog is based on the publication of our paper Russo, C., et al. Non-invasive screening of breast cancer from fingertip smears—a proof of concept study. Sci Rep 13, 1868 (2023). https://doi.org/10.1038/s41598-023-29036-7 in which was the 4th most downloaded cancer paper in 2023
DLGAP5 enhances bladder cancer chemoresistance by regulating glycolysis through MYC stabilization
Our study shows that DLGAP5 enhances gemcitabine resistance in bladder cancer by stabilizing MYC protein via USP11-mediated deubiquitination. This interaction boosts MYC-driven glycolysis, suggesting that targeting the DLGAP5-USP11-MYC axis could overcome resistance.
Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage
This study has recently been accepted in Signal Transduction and Targeted Therapy. The study reveals a new immune checkpoint of NK cells functional in the livers, a TM4SF5 and SLAMF7 linkage, and TM4SF5-specific isoxazole-based small molecules inhibitory against the linkage.
Trailblazing a Photostable Frontier: The Story of Phoenix Fluor 555
Young-Tae Chang (POSTECH, Korea): ytchang@postehc.ac.kr
https://www.nature.com/articles/s41592-024-02584-0
Intrapartum ultrasound image analysis
An automatic measurement of cervix dilation in intrapartum ultrasound image
Intravenous sedation for adults with profound acquired brain injury undergoing dental treatment - a seven-year service evaluation.
This blog describes an article written about dental care for patients with acquired brain injury, as well as the importance of intravenous conscious sedation as an adjunct.
Visualizing stepwise evolution of carbon hybridization from sp3 to sp2 and to sp
In our recent published paper in Nature Communications, we present the visualization of stepwise evolution in carbon hybridizations from sp3 to sp2 and to sp states via dehydrogenation and elimination reactions of methylcyano-functionalized molecules on surfaces.
