Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Culture-associated DNA hypermethylation of CAR T cells negatively affects therapeutic outcome
Analyzing effects of vitro expansion on the methylome of chimeric antigen receptor (CAR) T cells revealed loci with increased methylation that were also associated with reduced long-term survival in patients. These findings suggest that reduced cultivation periods may benefit clinical outcome.
A beginner's map of LY6E (and coronavirus control)
Behind-the-scenes, nostalgic rambling on the synthesis and completion of "LY6E is a pan-coronavirus restriction factor in the respiratory tract."
