Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Non-invasive diagnosis and surveillance of bladder cancer with driver and passenger DNAmethylation in a prospective cohort study
We studied DNA methylation markers in urine to enhance bladder cancer detection and classification. Our findings could transform non-invasive diagnosis and monitoring of this cancer and potentially other types as well, leading to major advances in cancer management with less invasive techniques.
Decoding sex-specific metabolomic biomarkers in the loggerhead sea turtle (Caretta caretta)
Is there a distinct metabolomic profile between male and female loggerhead turtles? Are there useful biomarkers for sex classification in this species?
Integrative single cell atlas revealed intratumoral heterogeneity generation from an adaptive epigenetic cell state in human bladder urothelial carcinoma
A subgroup of bladder cancer cells marked by TM4SF1 expression is a key source of tumor diversity (ITH). These cells, which show stem-cell features and foster various cell types within the tumor, are linked to more advanced cancer stages and poorer outcomes.
Unveiling the Mechanisms Behind Cancer Aggressiveness: How Epichaperomes Drive Cellular Plasticity
What makes cancer so aggressive and adaptable? Our latest research uncovers a hidden mechanism within cells—specialized protein networks called epichaperomes. These structures help cancer cells survive and thrive, reactivating developmental pathways and fueling unchecked growth.
A novel germline EGFR variant p.R831H causes predisposition to familial CDK12-mutant prostate cancer with tandem duplicator phenotype
This study is the first report identifying a pathogenic EGFR germline mutation in prostate cancer, suggesting venues for germline screening, non-invasive diagnosis and monitoring in clinical practice.
An Advanced Method to Predict Personality Traits by Combining Different Types of Information
Psychologists created the "Big Five" to group personality traits. New technology lets us study different types of data (text, audio, visual) to make more accurate predictions. Our research uses deep learning to improve this process.
The detection, biological function, and liquid biopsy application of extracellular vesicle-associated DNA
This review summarizes and discusses advances in EV-associated DNA (EV-DNA) research, with an emphasis on EV-DNA detection at the population-EV and single-EV levels, gene transfer-associated biological functions, and clinical applications as biomarkers for disease liquid biopsy.
The relationship between lifestyle habits and obesity among students in the Eastern province of Saudi Arabia: using the Arab Teens Lifestyle (ATLS) questionnaire
First study that administered the Arab Teens Lifestyle Study (ATLS) questionnaire among the university students of the Eastern Province of the Kingdom of Saudi Arabia
Mutations may offer clues to cancer development in systemic sclerosis
The latest paper from Natalie Saini's group explores an intriguing connection between inflammation, DNA damage, and cancer via accrual of somatic mutations in patients of systemic sclerosis (scleroderma).
