Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
DeepRTAlign: toward accurate retention time alignment for large cohort mass spectrometry data analysis
Retention time (RT) alignment is a crucial step in large cohort proteomics and metabolomics studies. Here, the authors introduce DeepRTAlign, a deep learning tool for RT alignment that shows high identification sensitivity and quantitative accuracy.
Body mass index, triglyceride-glucose index, and prostate cancer death: a mediation analysis in eight European cohorts
Analyzing data of over 250,000 European men, the TyG index, an indicator of insulin resistance, mediated part of the effect of BMI on prostate cancer death, thus supporting the hypothesis that insulin resistance might be an important pathway for obesity to accelerate prostate cancer progression.
Rescuing retromer in Parkinson's disease
Both Vp35 p.D620N and LRRK2 pathogenic variants cause late-onset, familial Parkinson's disease. In vivo, we show Vps35 p.D620N activates LRRK2 kinase activity, impairs the recycling and physiologic function of the dopamine transporter (DAT), and can be rescued by LRRK2 kinase inhibitors.
