Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Protein changes on the ultrafast timescale
In phytochrome Agp2 ultrafast proton-transfer occurs from the chromophore to a hydrogen-bonded water network in the protein prior to photoisomerization. The altered hydrogen bonds persist after photoisomerization and trigger together with the new chromophore geometry the activated protein conformation.
Rapid acceleration of pancreatic adenocarcinoma development by PPARδ hyperactivation
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with a rising incidence in the United States and globally. Effective strategies to prevent and treat PDAC are urgently needed. The majority of PDACs arise from pancreatic intraepithelial neoplasia (PanIN) pre-cancerous lesions.
"Concentriosome": A Compartment Without Permanent Boundaries
We have unearthed a new artificial organelle known as “Concentriosome” to carry out spatiotemporal enzymatic cascade reactions in solution and regiospecific chemical events using the standing waves that in turn are generated by the Faraday Instability setup.
High-resolution crystal structure of a 20 kDa superfluorinated gold nanocluster
The design, synthesis, and high-resolution single-crystal X-ray structure of a superfluorinated 20 kDa gold nanocluster was achieved. The nanocluster presents an Au25 core coated by a shell of multi-branched highly fluorinated thiols (SF27) resulting in almost 500 fluorine atoms.
Forest health in the time of a pandemic: how genomic biosurveillance discovered a new hybrid pathogen variant
Genomic biosurveillance of the pathogen responsible for sudden oak death in the United States and sudden larch death in Europe reveals a novel variant that is a hybrid between European and American lineages.
Describing the distribution of proteins on the cell surface
How can we quantify the nanoscale distribution of proteins on the cell surface? How can we tell if they are randomly distributed or not? The answer lies in a new data analysis method for single-molecule super-resolution microscopy.
