Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Fat and liver health: the view from LXRalpha
Fat accumulation in the liver is a defining feature of metabolic dysfunction associated steatotic liver disease and reduction of liver triglyceride is a major therapeutic goal. We show that a key driver of lipogenesis called LXRalpha may actually protect the liver by lowering liver cholesterol.
Electrochemical CO2 Reduction to Methane by Triazole Molecules
Electrochemical conversion of CO2 into fuels and chemicals with high selectivity and activity is crucial. Our recent work highlights a promising method for CO2-to-CH4 with considerable selectivity and industrially relevant activity by triazole molecules in the presence of trace metal impurities.
Preliminary Phase 2a Readout for a Novel Drug Discovered and Designed Using Generative AI Sets a Major Milestone in AI-Powered Drug Discovery
Insilico Medicine’s AI-Designed Small Molecule Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis Yields Positive, Promising Phase 2 Trial Data
Enabling transport and metabolism in synthetic cells
Decarboxylation of L-malate coupled to L-malate/L-lactate exchange provides metabolic energy for the uptake and metabolism of nutrients in cell-like lipid vesicles.
A promising nanotechnology to unlocking bladder cancer treatment
A non-invasive full-course NIR-II fluorescence imaging-navigated on-demand therapeutic strategy has been established with promises to optimize the treatment paradigm for bladder cancer.
