Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Uncovering the intracellular target of candidalysin
Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped.
Unraveling the Sugary Code: N-Glycosylation's Impact on Protein Conformation and its Link to Disease
In the intricate dance of cellular processes, a seemingly modest tweak known as N-glycosylation takes center stage. This post-translational modification endows proteins with a sophisticated sugar code, dictating their conformation, assembly, and, crucially, their roles in various diseases.
Graft T cells in hematopoietic stem cell transplant
Although the major complications of transplant (such as graft-versus-host disease, graft rejection, viral infections) are related to T cells, the graft size is determined by a surrogate marker for stem cells (CD34+) and not by T-cells. The graft T-cell content is rarely measured.
