Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Gene therapy meets cell therapy in the fight for sight
In the eye, a tiny pit in the central retina provides us the clearest vision of all. This region contains the highest number of cone photoreceptors – responsible for our daylight, high acuity vision. Unfortunately, several diseases lead to the degeneration of these photoreceptor cells.
High levels of AAV vector integration into CRISPR-induced DNA breaks
Using next-generation sequencing, we show that adeno-associated virus (AAV) DNA can cut-and-paste into CRISPR-induced breaks in the host genome.
