Targeting dysfunction of microRNA in MLL leukemia
In our latest manuscript in Leukemia, we describe a putative additional mechanism for MYC deregulation downstream of MLL. We further demonstrate that IRAK1/4 inhibitor might improve the efficacy of BET inhibitor through synergistically downregulating MYC in MLL leukemias.
Study on CUL4B , from Mental Retardation to Cancer
CUL4B is first identified as a mental retardation gene in our laboratory. We further confirmed that CUL4B also functions importantly in cancer. In our latest publication, we revealed CUL4B sustained the oncogenic properties in bladder cancer through regulating miR-372/373-PIK3CA/AKT axis.
Back to the basics: unraveling the role of hypoxia in PKA activation
Endocrine tumors frequently show PKA activation even in the absence of mutations in relevant genes. Here we used GH-secreting pituitary tumor cells to discover a novel mechanism through which hypoxia and HIF-1α activate PKA by altering the expression of the regulatory RIIB subunit.
The study of a novel candidate oncogene-C1orf35 in multiple myeloma
C1orf35 is a gene first cloned and identified in our laboratory, but little is known about its function. We confirmed it a candidate oncogene in the current study, and explored how it promote tumorigenesis.
