Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Unraveling the Genetic Mysteries of Psychiatric Disorders
This study integrated genetic, exon-level transcriptomic and single-cell data, pinpointing 110 core genes and shared pathways like circadian rhythm, cortisol, and dopamine signaling. Affected genes are key in excitatory neurons in the prefrontal cortex, suggesting links to cognitive issues.
New Tools for Screening for Enivronmentally Influenced Epigenetic Disease Risk Factors
We are studying how epigenetic modifications, changes to DNA structure that affect gene expression, without any DNA sequence changes, translate environmental exposures to disease risk. We have designed a new tool that will allow rapid screening to identify genes affected in any disease or exposure.
Programming Bacterial Communication for Teamwork in a Test Tube
Building bacterial communities that work together, like a team of specialists, is a promising way to create advanced biological computers. In this study, we combine a phage-based messaging system with CRISPR gene regulation, allowing Escherichia coli bacteria to process information collectively.
Pyroptosis as a Central Mechanism in Multisystem Toxicities Triggered by Environmental Pollutants
Pollution is bad for our health, but how exactly? Research says that one mechanism of cell death, pyroptosis, could be an important clue. Activated by pollutants, it leads to inflammation and damage to organs. To understand it can help us counteract pollution's long-term harm.
