Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Oncometabolite D-2-hydroxyglutarate—dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia
Cancer cachexia is characterized by weight loss and skeletal muscle wasting. The up-regulation of catabolism and down-regulation of anabolism result in concometabolite accumulation. This study focused on genetic mutation-mediated metabolic reprogramming in cancer cachexia progression.
Exploring Prolonged Drug Action: The Role of Epichaperome Agents
Discover the secret behind prolonged drug action. Epichaperome target binding by zelavespib and icapamespib defies rapid clearance, shedding light on effective disease treatment.