Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Breast cancer driven by germline TP53 mutations
We are excited to share our multi-omics analyses of breast cancers from patients with Li Fraumeni Syndrome, a cancer risk syndrome due to germline mutations in p53, the Guardian of the Genome.
The Goldilocks metabolite: why tissues need just enough L-2-HG
Our study reveals that L-2-hydroxyglutarate (L-2-HG), a metabolite often labeled as “toxic,” also has an essential physiological function in mice.
