Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Biomedical Research
World AIDS Day 2024: Multi-level perspectives on factors that impact hypertension screening, treatment, and management among people with HIV in South Africa
Most people with HIV live in low- and middle-income countries, where less than half with high blood pressure are diagnosed, and many go untreated. Understanding the barriers and facilitators to hypertension care in these settings can help create strategies to integrate hypertension and HIV care.
Room calorimetry the new gold standard for RMR measurements
For years the metabolic cart was considered the gold standard for measurement of resting metabolic rate. However, due to their inaccuracy and anxiety of people being placed under the ventilated hood, they are fast moving aside for the new gold standard in town...whole room indirect calorimetry.
Behind the Paper: A Bioinspired Journey to Needle-Free Drug Delivery
This blog post offers a glimpse into the research journey that led to our recent publication in Nature detailing microjet delivery (MiDe) systems for gastrointestinal drug delivery.
Human HDAC6 senses valine abundancy to regulate DNA damage
Valine specifically binds to the primate-specific SE14 repeat domain of HDAC6, retaining it in the cytoplasm. Valine deprivation triggers HDAC6 nuclear shift, increasing DNA demethylation and damage via TET2 activation. Valine restriction inhibits tumor growth, and enhances the effects of PARPis.
The effects of obesity
One of the unanswered questions about obesity is how it correlates with a myriad of diseases such as heart failure, coronary artery disease, type 2 diabetes, non-alcoholic fatty liver disease, osteoarthritis, and various cancers.
