Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Biomedical Research
Real-time disease monitoring predicts early relapse and refines conventional imaging in patients with DLBCL
Monitoring lymphoma treatment has long relied on PET-CT scans, but these are imperfect. Circulating tumor DNA (ctDNA) offers a minimally invasive, highly specific way to track disease in real time. In our study, we explored how ctDNA can reshape response assessment in DLBCL.
Passing Traits Without Genes: How the Gut Microbiome Transfers Behavior
Microbes can evolve faster than their hosts. We show that selecting only the microbiome, while keeping host genes fixed, can alter mouse behavior across generations. Microbes and their metabolites thus act as agents of adaptation, transmitting traits independently of host DNA.
Modeling t(4;11) leukemia in umbilical cord hematopoietic stem precursor cells
Chromosomal translocations of the KMT2A/MLL gene are frequently diagnosed in acute leukemia patients (ALL and AML) with very poor outcome. Here, we used the CRISPR/Cas9 technology to model this translocation t(4;11)(q21;q23) in hematopoietic stem cells deriving from umbilical cord blood.
Behind the Paper: Navigating the Hidden Hurdles of Science in Ecuador
Scientific progress thrives in the Global North with strong infrastructure and funding, but in the Global South like Ecuador, barriers abound. Our paper highlights non-traditional challenges: power outages , security threats halting fieldwork amid violence, and high import costs for equipment.
From Needles to Pills: The New Era of Weight-Loss Medicine
For years, people struggling with obesity have dreamed of a simple pill that could deliver real, lasting weight loss — without injections, surgery, or extreme diets.
That dream just came much closer to reality..
How Post-Translational Modifications Rewire Cellular Networks Through Epichaperomes
Proteins rarely work alone. Their functions emerge from networks of interactions—dynamic connections that continuously reorganize to maintain cellular balance. But what happens when this balance is lost?
Overcoming Chemotherapy Resistance in Head and Neck Cancer using PI3K Inhibition
Head and neck squamous cell carcinoma (HNSCC) is almost uniformly fatal when it recurs following definitive treatment with chemoradiation. To address this critical therapeutic gap, our team investigated inhibition of the phosphoinositide 3-kinase (PI3K) pathway.
Rein in or Ruin: Ubiquitylation of CDC42 Ensures Membrane Homeostasis and Regulates Brain Development
The small Rho GTPase CDC42 drives actin polymerization and membrane protrusion. Unchecked cytoskeletal remodeling can push tumor cells toward EMT or even cell death. Thus, elucidating how cells both activate and quench CDC42 signaling to maintain membrane homeostasis has been a central question.
Breaking the Silence: Ethnic Inequalities in Cancer Pain Relief in the UK
Our study, published in the British Journal of Cancer, reveals patients with cancer from minority ethnic backgrounds in England are prescribed fewer opioids for pain relief at the end of life and require more emergency department visits, highlighting urgent inequalities in palliative care
