A Grand Challenge
Stapled α-helical peptides, can bind to and modulate therapeutic targets that have been historically out of reach with traditional modalities. However, it has been challenging to design stapled peptides that have both good cell permeability and behave well. Our team aimed to address this challenge.
A Retrospective Analysis of Biliary Tract Cancer Patients Presented to the Molecular Tumor Board at the Comprehensive Cancer Center Munich
With the rising importance of precision oncology in biliary tract cancer (BTC), this analysis describes the clinical and molecular characteristics of this patients.
Unveiling the Journey Behind a Breakthrough in Early Detection of Pancreatic Cancer
New paper demonstrates effectiveness of exosome isolation technology in detecting Stage I and II pancreatic ductal adenocarcinoma (PDAC)
A call for individual risk stratification on early morbidity and mortality in patients with newly diagnosed multiple myeloma
Behind the paper of „Predictors of early morbidity and mortality in newly diagnosed multiple myeloma: data from five randomized, controlled, phase III trials in 3700 patients” - an international team effort from the HOVON, EMN and GMMG study groups.
USP43 stabilizes c-Myc to promote glycolysis and metastasis in bladder cancer
This study identified USP43 as a deubiquitinase which regulates glycolytic metabolism and c-Myc transcriptional activity and revealed a USP43/c-Myc positive feedback loop that contributes to the progression of BLCA.
Computational pathology identifies immune-mediated collagen disruption to predict clinical outcomes in gynecologic malignancies
A computational pathology tool to quantitatively characterize the immune-collagen relationship in gynecologic cancers. It enables prognostic stratification of patients and provides insights into the biology of the tumor microenvironment.
TRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC
This study identified the significant role of TRAIP in inhibiting BLCA progression, and revealed that TRAIP expression is significantly downregulated in BLCA and is strongly associated with poor prognosis.