Active Autophagy May Be Good for Survivals of Cancer Patients
Mutants in LRPPRC gene was found to be associated with French Canadian Type Leigh syndrome. Here we used a mouse model to confirm that LRPPRC acted through P62 and HDAC6 to activate autophagy and through Yap and P27 to maintain genome stability so that hepatocellular carcinoma was suppressed.
PBRM1: A Potential Negative Predictive Biomarker for immunotherapy in NSCLC
In our research, PBRM1 mutation was found to be a negative predictive biomarker of immunotherapy efficacy in NSCLC. Patients with PBRM1 mutation got less survival benefit from immunotherapy for NSCLC.
