Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Mycofluidics of clocks in single filaments of Neurospora crassa
We show single filaments in the model system Neurospora crassa have a biological clock. We also develop model of the clock in single filaments that is supported by microfluidics data and provides an explanation for long distance (mm) synchronization of clocks in filaments.
Exploring SHANK3 in Neurodevelopment Using Stem Cells and Chemical Biology
Here we delve into our research on Phelan-McDermid syndrome (PMDS), a rare genetic disorder. We focused on SHANK3, an integral protein in neurodevelopment and synaptic function. We explore potential treatment strategies for PMDS, aiming to contribute to drug discovery in neurodevelopmental diseases.
Unveiling Single-Cell Resolution Insights into Epichaperomes in Tissues: Introducing the PU-TCO Clickable Epichaperome Probe
Discovering the secrets of neurodegenerative diseases and cancer at single-cell level precision - the PU-TCO clickable probe illuminates epichaperomes, offering insights into disease mechanisms at a cellular level.
A new automated, multiplex approach to studying shear stress mechanotransduction of circulating cells
As the mechanobiology of immune and cancer cells is gaining interest, we developed an easy to adopt, off-the-shelf system for subjecting many different samples to repeated cycles of fluid shear stress.
Behind the paper: Unraveling the molecular mechanism behind COVID-19 pulmonary pathologies associated with ferroptosis
How we found that ferroptosis is a key driver of lung damage in severe COVID-19 patients,
By Baiyu Qiu, Fereshteh Zandkarimi, Anjali Saqi and Brent R. Stockwell
Particle contaminants as potential disruptors of biomolecular condensates
Polystyrene nanoplastics trigger amyotrophic lateral sclerosis (ALS)-associated TAR DNA binding protein-43 (TDP-43) to undergo aberrant phase separation and exacerbate pathogenic tendency via persistent intracellular stimulation and direct interaction.
Essential Fatty Acids: A Potential Solution for Post-COVID-19 Long-Haul Manifestations
This blog was written by Undurti N. Das. Prof. Das is a clinical immunologist, endocrinologist and the founder president and chief executive officer of UND Life Sciences.
