Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Recessive ReNU2 syndrome: highly prevalent and potentially treatable
Genetic variants in a small noncoding gene called RNU2-2 are responsible for the most prevalent known recessive neurodevelopmental disorder. It may also be amongst the disorders amenable to treatment with gene replacement therapy.
Closing the loop on HIV-1 circRNAs: Discovery of a functional HIV-encoded circRNA that impacts viral gene expression
Can an RNA virus encode circular RNAs (circRNAs)? Following that question through HIV-1 led us to circHIV, a viral circRNA that promotes HIV-1 transcription through Tat.
Human neuronal differentiation under Aβ exposure: a single-cell transcriptomic and epigenomic dataset
What happens when developing human neurons encounter amyloid-β, one of the central molecules linked to Alzheimer’s disease? We followed human neural progenitor cells as they differentiated into neurons to examine how early Aβ exposure reshapes this process.
