Unlocking the Molecular Mechanisms of BSEP Dysfunction: Toward Precision Therapies for PFIC2
From protein structure to precision medicine – how structural perturbations in a membrane protein may offer a blueprint to creating targeted therapies for a rare childhood genetic disease.
Imaging glioma metabolism
We sought evidence for the presence of metabolic subtypes in the tumours of glioblastoma patients by infusing the patients with 13C-labelled glucose immediately prior to surgery and then rapidly freezing the excised tumour and subjecting tumour sections to mass spectrometry imaging.
Engineering alcohol dehydrogenase for better utilization of nicotinamide cofactor biomimetics
Jiangnan Univ's Prof. Ye Ni discovered the first natural ADH utilizing synthetic NCBs, advancing synthetic biology & industrial enzyme engineering for enhanced biocatalysis.
Behind the Paper: Potent antagonist for the MAS-related G protein-coupled receptor and its mouse ortholog with anti-inflammatory, anti- asthmatic, and anti-anaphylactic efficacy in human mast cells and mice
This is the story behind the paper by Al Hamwi et al., recently published in Signal. Transduct. Target. Ther. 2025, 10, 128. doi: 10.1038/s41392-025-02209-8.
Nanopore -based ELISA
Providing a new signal output method for enzyme-linked immunosorbent assay (ELISA)
