Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Neuroscience
Laromestrocel: Stem Cells for Alzheimer's Disease?
Treatment of Alzheimer’s disease has seen recent advancement with anti-amyloid therapies, but these are only partially effective and come with risks. Stem cell treatments offer new promise, and new clinical trial results point to both safety and potential efficacy.
Structure of human mGlu3-arrestin complex
In this paper, we reported the structures of two mGlu3-βarr1 complex with 2:1 and 2:2 stoichiometries. The mGlu3 in an inactive conformation engages βarr1 through phosphorylated C-terminal tail and intracellular loops.
Four-Scene Circumstances: A Tale of Visual Complexity and Origin
The brain is one of the most intricate structures in life. Its complexity is a result of the vast diversity of neuron types that shapes various aspects of behavior and ultimately determines each species’ survival.
Targeting Stem Cells in Medulloblastoma
Here, we tested the hypothesis that OLIG2, a key transcriptional regulator of neural development, plays a crucial role in maintaining cancer stem cells (CSC) in medulloblastoma tumors that can be exploited using a new type of targeted therapy.
Targeting Cell Fate Transitions in Medulloblastoma: Precision and Context Matter
Research from my lab led by Kinjal Desai, out today in Nature Communications, probes cell fate transitions in the medulloblastoma hierarchy. By blocking OLIG2, which drives the transition from quiescence to proliferation in the neoplastic stem cells, we block de novo tumour formation and regrowth.