Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Neuroscience
Dual-vector rAAVrh8 gene therapy for GM2 Gangliosidosis: a Phase I/II trial
This is a dose escalation of a dual AAV vector gene therapy for Tay-Sachs and Sandhoff diseases in which a novel bithalamic infusion process was used. The broad distribution of axonal connections of thalamic neurons enables transport of the normal B-hexosaminidase A enzyme throughout the cerebrum.
The crosstalk between CREB and PER2 mediates the transition between mania- and depression-like behavior
Published in Neuropsychopharmacology volume 50, pages1683–1694 (2025)
Key Role of the CRE Sequence in the Per1 Promoter in Mediating the Switch Between Unipolar and Bipolar Depression‐Like Behaviors
Published in Journal of Pineal Research, 2025, https://doi.org/10.1111/jpi.70095
Making the Most of Brain Dock: Translating a Uniquely Japanese Screening Tradition into Evidence for Primary Stroke Prevention
Brain Dock is Japan's preventive MRI programme for identifying asymptomatic cerebrovascular abnormalities in apparently healthy individuals. Asymptomatic brain lesions are established stroke risk markers, but evidence that lesion-guided intervention reduces future events remains limited.
Thalamus: A practical platform for real-time multimodal data capture in clinical neuroscience
Thalamus is a real-time system for synchronizing neural and behavioral data across multiple devices, built to meet the demands of modern clinical neuroscience. In this post, we take a behind-the-scenes look at how the system was developed, and the practical challenges that motivated its design.
