Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Overcoming immunotherapy resistance in melanoma defective of IFN-g signaling
Melanoma loss of IFN-g signaling is a major mechanism of resistance to immune checkpoint blockers such as anti-CTLA-4 and anti-PD-1, a prominent type of immunotherapies offering unprecedented therapeutic hopes to melanoma patients. However, strategies of overcoming this resistance have been elusive.
De novo-designed light-activated Reaction Centers pave the way toward new photosynthetic pathways
Proteins designed from scratch reproduce the multi-step electron transfer cascade that leads to charge separation in photosynthesis.
The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence
Infections caused by Pseudomonas aeruginosa are difficult to threat for many reasons. Among them, P. aeruginosa shows intrinsic or acquired resistance to several antibiotics. It expresses virulence factors and adopts specific lifestyles, like biofilms, non-responsive to antibiotics.
