Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Evaluation of the Humoral Immune Response and Milk Antibody Transfer in Cattle vaccinated with inactivated H5 Avian Influenza vaccine
The detection of Highly Pathogenic Avian Influenza (HPAI) A(H5N1) in dairy cattle in the United States has raised concerns about human exposure.
High-valence bismuth(V) nanoplatform to potentiating tumor immunotherapy
A high-valence bismuth(V) nanoplatform has been proposed for the first time for triggering cancer cell death and anti-tumor immune responses via an exogenous excitation-free and endogenous H2O2- and O2-independent reactive oxygen species generation behavior.
Isolation of a planar π-aromatic Bi5– ring in a cobalt-based inverse sandwich-type complex
Monocyclic aromatic molecules are well-known in organic chemistry and for coordination chemistry. In contrast, isoelectronic cycles comprising (semi)metal atoms only are much rarer. We present Bi5−, the so far elusive heaviest analogue of (C5H5)− which we trapped in an inverse-sandwich-type complex.
Extreme heatwaves could intensify much more than expected with climate change
It is known that heatwaves become more severe as the climate warms. But a new study led by the University of Graz now shows that the most extreme heat events may intensify much stronger than previously expected.
How I discovered your fingertips could detect cancer!
This invited blog is based on the publication of our paper Russo, C., et al. Non-invasive screening of breast cancer from fingertip smears—a proof of concept study. Sci Rep 13, 1868 (2023). https://doi.org/10.1038/s41598-023-29036-7 in which was the 4th most downloaded cancer paper in 2023
DLGAP5 enhances bladder cancer chemoresistance by regulating glycolysis through MYC stabilization
Our study shows that DLGAP5 enhances gemcitabine resistance in bladder cancer by stabilizing MYC protein via USP11-mediated deubiquitination. This interaction boosts MYC-driven glycolysis, suggesting that targeting the DLGAP5-USP11-MYC axis could overcome resistance.
Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage
This study has recently been accepted in Signal Transduction and Targeted Therapy. The study reveals a new immune checkpoint of NK cells functional in the livers, a TM4SF5 and SLAMF7 linkage, and TM4SF5-specific isoxazole-based small molecules inhibitory against the linkage.
Trailblazing a Photostable Frontier: The Story of Phoenix Fluor 555
Young-Tae Chang (POSTECH, Korea): ytchang@postehc.ac.kr
https://www.nature.com/articles/s41592-024-02584-0
