Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Developing a therapeutic RNA base editing platform
Wave was founded on the idea that controlling backbone stereochemistry has potential to improve chemically modified oligonucleotide therapeutics. We now report a stereopure RNA base editing platform, adding a new modality that can help us deliver transformational therapies for patients .
Tomographic measurement of dielectric tensors at optical frequency
We developed dielectric tensor tomography – a method to directly measure and reconstruct the 3D dielectric tensors of anisotropic samples
Density of states prediction for materials discovery via contrastive learning from probabilistic embeddings
Few machine learning models consider materials' multi-property prediction, such as the density of states. We propose a novel machine learning model, called Mat2Spec, for predicting ab initio phonon and electronic density of states for crystalline materials.
Making bubbles in Veillonella parvula – not child’s play
We analyzed the distribution of outer membrane (OM) attachment mechanisms across the whole tree of Bacteria, and we made a hypothesis on how gram-positives might have emerged. We tested it by perturbing OM tethering in the diderm Firmicute Veillonella. The results surprised us!
Identifying causal relationships of cancer treatment and long-term health effects among 5-year survivors of childhood cancer in Southern Sweden
Survival after childhood cancer has improved but adverse so-called late effects are evident. Research on late effects can improve treatments and follow-up. Our study developed and used a method, based on AI techniques, to make causal associations between childhood cancer, treatments, and outcomes.
A vivid snapshot of human activities 40,000 years ago in Eastern Asia
A well-preserved archaeological site in China reveals a window into hunter-gatherer lifestyle 40,000 years ago. Excavations at the site of Xiamabei, in the Nihewan Basin, have revealed the presence of innovative and unique toolkits, illustrating more cultural diversity than previously realised.
