We propose in this study an iminium ion/enamine tandem sequence that could efficiently overcome energy barriers encountered in Michael and aldol reactions during [3+2] annulations of acyl pyridines and α,β-unsaturated aldehyde for the construction of diverse indolizine-2-carbaldehydes.
The enhanced permeability and retention (EPR) effect of tumours is a topic of debate in nanomedicine community. To address this, we established a single-vessel quantitative analysis method (nano-ISML) to reveal heterogeneity of tumour vascular permeability.
Imaging phage resistance in real time: The role of the Lsr2 protein in phage infection of Mycobacteria is shown using novel microscopy and engineered phages.
A new platform to construct alkylated quaternary stereogenic carbon centers at the propargylic position by reaction with free alkyl radicals!
We note that more than 70% area of the Indian landmass has experienced significant changes in characteristics of temperature extremes due to soil moisture perturbations, through modulating surface energy partitioning, evapotranspiration and soil moisture memory.
The detailed functional study of rare and unusual genomic events in patient cancer samples can provide some unique and important biological insights. We have uncovered a novel mechanism of tyrosine kinase activation in a form of leukaemia in which tyrosine kinase activation is the hallmark.