Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
We propose in this study an iminium ion/enamine tandem sequence that could efficiently overcome energy barriers encountered in Michael and aldol reactions during [3+2] annulations of acyl pyridines and α,β-unsaturated aldehyde for the construction of diverse indolizine-2-carbaldehydes.
Heterogeneous EPR in tumour
The enhanced permeability and retention (EPR) effect of tumours is a topic of debate in nanomedicine community. To address this, we established a single-vessel quantitative analysis method (nano-ISML) to reveal heterogeneity of tumour vascular permeability.
Soil moisture revamps the temperature extremes in a warming climate over India
We note that more than 70% area of the Indian landmass has experienced significant changes in characteristics of temperature extremes due to soil moisture perturbations, through modulating surface energy partitioning, evapotranspiration and soil moisture memory.
Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL
The detailed functional study of rare and unusual genomic events in patient cancer samples can provide some unique and important biological insights. We have uncovered a novel mechanism of tyrosine kinase activation in a form of leukaemia in which tyrosine kinase activation is the hallmark.