How Post-Translational Modifications Rewire Cellular Networks Through Epichaperomes
Proteins rarely work alone. Their functions emerge from networks of interactions—dynamic connections that continuously reorganize to maintain cellular balance. But what happens when this balance is lost?
Beyond the Headlines: Ensuring Integrity While Advancing Alzheimer’s Research
How do we ensure scientific integrity while advancing urgently needed treatments? Sensationalized media narratives aren’t the answer. While accountability is essential, we must also recognize the groundbreaking research that brings us closer to real solutions for Alzheimer’s and other diseases.
Unveiling the Mechanisms Behind Cancer Aggressiveness: How Epichaperomes Drive Cellular Plasticity
What makes cancer so aggressive and adaptable? Our latest research uncovers a hidden mechanism within cells—specialized protein networks called epichaperomes. These structures help cancer cells survive and thrive, reactivating developmental pathways and fueling unchecked growth.
Dysfunctional Protein-Protein Interactome (dfPPI): A Platform for Systems-Level Analysis of PPI Alterations in Disease
Explore Dysfunctional Protein-Protein Interactome (dfPPI): Revealing how aberrant protein interactions drive cancer and neurodegeneration, guiding mechanistic insights and therapeutics innovations.
Unveiling Single-Cell Resolution Insights into Epichaperomes in Tissues: Introducing the PU-TCO Clickable Epichaperome Probe
Discovering the secrets of neurodegenerative diseases and cancer at single-cell level precision - the PU-TCO clickable probe illuminates epichaperomes, offering insights into disease mechanisms at a cellular level.
Unraveling the Sugary Code: N-Glycosylation's Impact on Protein Conformation and its Link to Disease
In the intricate dance of cellular processes, a seemingly modest tweak known as N-glycosylation takes center stage. This post-translational modification endows proteins with a sophisticated sugar code, dictating their conformation, assembly, and, crucially, their roles in various diseases.
Exploring Prolonged Drug Action: The Role of Epichaperome Agents
Discover the secret behind prolonged drug action. Epichaperome target binding by zelavespib and icapamespib defies rapid clearance, shedding light on effective disease treatment.
Unveiling the Intricate Dance of HSP90: A Master Conductor of Cellular Responses in Health and Disease
In the intricate world of cellular responses, a molecular maestro plays a pivotal role – HSP90. What makes HSP90 truly fascinating is its conformational flexibility. Scientists are now uncovering the profound impact of HSP90's conformational changes on cellular responses in health and disease.
Epichaperomics: Illuminating the Secrets of Protein Interactions in Disease Research
Introducing Epichaperomics: an emerging omics platform for research to illuminate the secrets of diseases. By studying protein interactions in cells and tissues, it offers valuable insights into disease mechanisms and paves the way for personalized therapies.
Unveiling the Role of Protein Glycosylation: Insights into Conformational Dynamics and Disease Mechanisms
Glycosylation plays a critical role in controlling normal cell functions as well as disease-related conditions. Understanding how sugar modifications impact proteins, including their conformations and interactions, is crucial for unraveling the causes of diseases and developing targeted treatments.
Cornering the interactome to kill cancer cells
Joshi et al reveal how manipulating cancer cell protein-protein interactions networks (i.e. interactomes) eliminates rebound pathways, turning traditionally less effective therapeutics highly efficacious.