Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
New Tools for Screening for Enivronmentally Influenced Epigenetic Disease Risk Factors
We are studying how epigenetic modifications, changes to DNA structure that affect gene expression, without any DNA sequence changes, translate environmental exposures to disease risk. We have designed a new tool that will allow rapid screening to identify genes affected in any disease or exposure.
Targeting rewired metabolic pathways in pancreatic cancer
Pancreatic cancer cells rewire their metabolism to adapt to their nutritional environment. In this study, we show that targeting a new drug target, PIKfyve, disrupts lipid metabolism and sensitizes pancreatic cancer cells to KRAS-MAPK inhibitors.
Support for Diversity and the Racial Status Quo in Lay and Legal Samples
Attitudes that favor the racial status quo undergird how White Americans selectively embrace diversity and may inform the legal decision-making affecting universities’ right to race-conscious practices.
Unraveling the Puzzle of Human Migration in Floodplains
Flood fatalities and displacement influence human migration in floodplains of developing countries
A Chat in the Hallway Leads to Discovery
What can lead to new discovery in science? In this story behind the paper, a chat in the hallway at Argonne sparked a long and fruitful collaboration leading to a significant discovery of effective additives for lithium-ion batteries (LIBs).
CARPID: Capture RNA-Protein interactions in living cells
We developed CARPID method to identify binding proteins of specific lncRNAs in the native cellular context, which jointly leverages enzymatically inactive CRISPR/dCasRx-based RNA targeting and proximity biotin-labeling.
