Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage/autophagy pathways
Pectolinarigenin (PEC) from herbal medicine targets DNA topoisomerase II alpha (TOP2A) in bladder cancer (BLCA), causing DNA damage and blocking cell division. It inhibits autophagy, boosting its effectiveness. Combined with gemcitabine, PEC more effectively halts BLCA growth.