Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Treating space flight-induced bone loss: boldly going where no mouse has gone before
With support from the Center for the Advancement of Science in Space (CASIS), a team from University of California, Los Angeles (UCLA) and the Forsyth Institute shows that injecting mice with a bone-homing version of a bone growth-promoting protein can prevent space flight-induced bone loss.
How the vasculature controls adipose tissue wasting in cancer cachexia
Tissue wasting occurs frequently in patients with advanced cancer. Here, researchers show that the vasculature in adipose tissue responds to tumor-secreted factors by the release of soluble molecules (so called angiokines) acting in a paracrine manner to amplify wasting of white adipose tissue.
Oncometabolite D-2-hydroxyglutarate—dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia
Cancer cachexia is characterized by weight loss and skeletal muscle wasting. The up-regulation of catabolism and down-regulation of anabolism result in concometabolite accumulation. This study focused on genetic mutation-mediated metabolic reprogramming in cancer cachexia progression.
