Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Blood clotting and tissue healing
The number of blood clots in society is expected to double by 2050. The risk of blood clotting increases significantly after injury, surgery, or leg immobilization. However, the effects of blood clots on tissue healing and the underlying regulatory mechanisms remain largely unknown.
Structure of human mGlu3-arrestin complex
In this paper, we reported the structures of two mGlu3-βarr1 complex with 2:1 and 2:2 stoichiometries. The mGlu3 in an inactive conformation engages βarr1 through phosphorylated C-terminal tail and intracellular loops.
PGRMC2: The discovery of pressure-volume regulator
Using different techniques, our study suggests the important role of PGRMC2 as a pressure-volume regulator in the heart.
