Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Biomedical Research
Bridging the Gap: Enhancing Diversity in Clinical Trials to Advance Medicine
Breakthroughs to advance human health require clinical trials that include communities less engaged in research and development of potentially lifesaving medical interventions. To address this, a coalition created the Equitable Breakthroughs in Medicine Development Site Maturity Assessment Model.
Sustaining Immunity against Rabies: Insights from Cambodia's Post-Exposure Prophylaxis Protocol
Our study from the Institut Pasteur du Cambodge explores the long-term immunity of Cambodia’s rabies post-exposure prophylaxis protocol. It highlights antibody and T-cell responses, supporting efforts to control rabies with innovative, resource-efficient strategies in low-resource settings.
Changing the paradigm for immuno-monitoring
Humoral immune response is difficult to quantify due to the lack of calibrators that encompass the diversity of its polyclonality. Therefore, the best assessment can be obtained by titration method. Antibody titer is represented by the last dilution producing a positive signal in a given technique.
Does Increased Energy Production in the Brain Influence Suicidal Behavior?
Recent research sheds light on the role of brain metabolism in suicidal behavior, focusing on a region called parahippocampal cortex (PHC). The PHC plays a role in emotions, decision-making, and memory. People with depression or a history of suicide attempts often show abnormal activity in the PHC.
Proteomic analysis of the combined effects of cannabigerol and 3-O-ethyl ascorbic acid on kinase-dependent signalling in UVB-irradiated human keratinocytes
Phytocannabinoid CBG together with EAA, a stable, lipophilic derivative of the vitamin C, recovered human skin cells irradiated by UV light. Their effects on kinases were manifested even after 24 hours.
Effects of CBG and EAA were linked to reduced modification of keratinocyte proteins by 4-HNE.
World AIDS Day 2024: Multi-level perspectives on factors that impact hypertension screening, treatment, and management among people with HIV in South Africa
Most people with HIV live in low- and middle-income countries, where less than half with high blood pressure are diagnosed, and many go untreated. Understanding the barriers and facilitators to hypertension care in these settings can help create strategies to integrate hypertension and HIV care.
Room calorimetry the new gold standard for RMR measurements
For years the metabolic cart was considered the gold standard for measurement of resting metabolic rate. However, due to their inaccuracy and anxiety of people being placed under the ventilated hood, they are fast moving aside for the new gold standard in town...whole room indirect calorimetry.
Behind the Paper: A Bioinspired Journey to Needle-Free Drug Delivery
This blog post offers a glimpse into the research journey that led to our recent publication in Nature detailing microjet delivery (MiDe) systems for gastrointestinal drug delivery.
Human HDAC6 senses valine abundancy to regulate DNA damage
Valine specifically binds to the primate-specific SE14 repeat domain of HDAC6, retaining it in the cytoplasm. Valine deprivation triggers HDAC6 nuclear shift, increasing DNA demethylation and damage via TET2 activation. Valine restriction inhibits tumor growth, and enhances the effects of PARPis.
