Decoding Radiation-Induced Fibrosis: a computational approach to understanding the damage pathway
Computational modeling of radiation-induced lung fibrosis via the agent-based paradigm provides valuable insights into the initiation and progression of toxicity.
A Detour for Prostate Cancer Cell Survival and Growth
Second generation AR antagonists, abiraterone and enzalutamide, induce aberrant HGF/MET and Wnt pathways leading to increased XPO1 expression and ribosomal biosynthesis in double-null prostate cancer (DNPC). However, treatment with XPO1 and ribosomal inhibitors showed an improved antitumor response.
PD-1 expression in γδ T cells: What does this mean?
Here, we explore the immunological relevance of PD-1 expression in tissue resident Vδ1+ γδ T cells and discuss the subsequent implications for cancer immunotherapy.
Omomyc is finally in the clinic. What a journey!
MYC is the most deregulated oncogene in human cancer, where it directs transcriptional programs that allow cancer cells to thrive and survive therapies. Despite being a most wanted target in cancer treatment, it has been long considered undruggable.
Neoantigen Vaccine Nanoformulations based on Chemically Synthesized Minimal mRNA (CmRNA): Small Molecules, Big Impact
Our npj Vaccines article unveils a prospective breakthrough in personalized cancer immunotherapy, featuring Chemically Synthesized Minimal mRNA (CmRNA) in Lipid-Polymer Hybrid Nanoparticles (LPPs). This idea not only answers ongoing research needs but propels a paradigm shift in cancer treatment.
