Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA
LncRNA HDRACA is involved in the high-density lipoprotein (HDL) regulation of angiogenesis. Normal HDL (nHDL) inhibits the expression of HDRACA to induce angiogenesis, and dysfunctional HDL (dHDL) is much less effective in inhibiting HDRACA expression and inducing angiogenesis.
Unveiling the Intricate Dance of HSP90: A Master Conductor of Cellular Responses in Health and Disease
In the intricate world of cellular responses, a molecular maestro plays a pivotal role – HSP90. What makes HSP90 truly fascinating is its conformational flexibility. Scientists are now uncovering the profound impact of HSP90's conformational changes on cellular responses in health and disease.
An atlas showing the genetic modifications occurring in all dental pulp cell populations upon carious insult in human teeth
The recent Editor’s Choice article published in the International Journal of Oral Science provides the first comprehensive single-cell atlas of dental caries. The study provides an unprecedented view of molecular and cellular changes occurring in the tooth dental pulp upon carious lesion
Culture-associated DNA hypermethylation of CAR T cells negatively affects therapeutic outcome
Analyzing effects of vitro expansion on the methylome of chimeric antigen receptor (CAR) T cells revealed loci with increased methylation that were also associated with reduced long-term survival in patients. These findings suggest that reduced cultivation periods may benefit clinical outcome.
Epichaperomics: Illuminating the Secrets of Protein Interactions in Disease Research
Introducing Epichaperomics: an emerging omics platform for research to illuminate the secrets of diseases. By studying protein interactions in cells and tissues, it offers valuable insights into disease mechanisms and paves the way for personalized therapies.
Unveiling the Role of Protein Glycosylation: Insights into Conformational Dynamics and Disease Mechanisms
Glycosylation plays a critical role in controlling normal cell functions as well as disease-related conditions. Understanding how sugar modifications impact proteins, including their conformations and interactions, is crucial for unraveling the causes of diseases and developing targeted treatments.
CRISPR Off-Targets: One SNP can make all the difference
In a recent paper, we used ultra-deep sequencing to determine whether CRISPR was introducing or enriching for mutations in cancer genes.
Cornering the interactome to kill cancer cells
Joshi et al reveal how manipulating cancer cell protein-protein interactions networks (i.e. interactomes) eliminates rebound pathways, turning traditionally less effective therapeutics highly efficacious.
