Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Aging as the Wound That Fails to Heal — A Bioenergetic Continuum of Resolution Failure
Aging often looks less like wear and tear and more like a wound that cannot finish healing. This Perspective explores how chronic stress, metabolic misallocation, and mitochondrial congestion create a bioenergetic bottleneck that prevents full recovery and drives aging.
Discovering a molecular protective shield in a prebiotic environment
We show that AMP enables specific, mineral-assisted reduction of the redox coenzyme NAD. In a prebiotic context, this means that the non-functional AMP handle could have served a pre-enzymatic purpose.
Mapping the substrates of human pseudouridine synthases
In our recent paper published in Nature Cell Biology, we report the first comprehensive map of pseudouridine (Ψ) modifications dependent on stand-alone pseudouridine synthases (PUS) in human transfer RNAs (tRNAs).
The forensics of mobile mRNA data in plants
This is an account of my personal journey through a project that involved many collaborators, and ended up challenging a whole research field.
Unlocking the Role of Long Non-Coding RNAs in Multiple Myeloma: The LINC01432–CELF2 Axis
By combining clinical genomics with RNA biology, we uncovered a new mechanism through which a long non-coding RNA helps myeloma cells evade apoptosis, while training the next generation of scientists to make new discoveries.
How Post-Translational Modifications Rewire Cellular Networks Through Epichaperomes
Proteins rarely work alone. Their functions emerge from networks of interactions—dynamic connections that continuously reorganize to maintain cellular balance. But what happens when this balance is lost?
