Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Unlocking mushroom treasures: the untold story for reconstructing the biosynthetic network of type II ganoderic acids in engineered yeast
Type II ganoderic acids (TIIGAs) have excellent medicinal value and can also be serve as valuable nutraceutical ingredients, yet their natural production remains limited. We have deciphered the biosynthetic network of TIIGAs and established a platform for their efficient production in yeast.
Fueling the failing heart: Meta-analysis identifies metabolic treatment strategies for heart failure.
Stimulating cardiac fatty acid oxidation or glucose oxidation may considerably improve heart function in models of heart failure.
A PurFect strategy for tuberculosis drug discovery?
Tuberculosis treatment urgently needs new drugs targeting novel pathways. Here, we present a new compound which inhibits PurF, a key enzyme in purine biosynthesis. These findings offer a promising strategy to tackle drug-resistant TB and enhance the effectiveness of current treatment regimens.
Unlocking the Molecular Mechanisms of BSEP Dysfunction: Toward Precision Therapies for PFIC2
From protein structure to precision medicine – how structural perturbations in a membrane protein may offer a blueprint to creating targeted therapies for a rare childhood genetic disease.
Unraveling the Genetic Mysteries of Psychiatric Disorders
This study integrated genetic, exon-level transcriptomic and single-cell data, pinpointing 110 core genes and shared pathways like circadian rhythm, cortisol, and dopamine signaling. Affected genes are key in excitatory neurons in the prefrontal cortex, suggesting links to cognitive issues.
