Unveiling the Mechanisms Behind Cancer Aggressiveness: How Epichaperomes Drive Cellular Plasticity
What makes cancer so aggressive and adaptable? Our latest research uncovers a hidden mechanism within cells—specialized protein networks called epichaperomes. These structures help cancer cells survive and thrive, reactivating developmental pathways and fueling unchecked growth.
The detection, biological function, and liquid biopsy application of extracellular vesicle-associated DNA
This review summarizes and discusses advances in EV-associated DNA (EV-DNA) research, with an emphasis on EV-DNA detection at the population-EV and single-EV levels, gene transfer-associated biological functions, and clinical applications as biomarkers for disease liquid biopsy.
Visible light accelerates skin wound healing and alleviates scar formation in mice by adjusting STAT3 signaling
In mice keratinocytes, upregulation of PI3Kβ by red light promotes the p-STAT3 and accelerates skin wound healing by; ROS induced by blue light inhibits the p-STAT3 and alleviates scar formation.
Unique Antibiotic Family
New antibiotics are a massive unmet need. The rise in antibiotic resistant bacteria is ever increasing such that antimicrobial resistance contributed to 5 million death last year, the next pandemic could be bacterial, and there are some conditions for which current antibiotics are ineffective.
Unravelling the bioactive potential of a bacterial symbiont of a tropical bird
Novel Amycolatopsis sp. PS_44_ISF1 isolated from the uropygial gland of Pachycephala schlegelii possesses the ability to produce a series of bioactive compounds, including two novel families of metabolites. Our study exemplifies the underexplored chemical potential of bacterial symbionts of birds.
