Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: General & Internal Medicine
Exploring SHANK3 in Neurodevelopment Using Stem Cells and Chemical Biology
Here we delve into our research on Phelan-McDermid syndrome (PMDS), a rare genetic disorder. We focused on SHANK3, an integral protein in neurodevelopment and synaptic function. We explore potential treatment strategies for PMDS, aiming to contribute to drug discovery in neurodevelopmental diseases.
New tricks from old drugs: repurposing the 80s
A paper in Molecular Psychiatry describes a new cell biological mechanism regulated by antidepressants, showing how a single dose of a drug fluvoxamine may open up the brain for drug delivery. Can this finding signal the beginning of a brand new career for the 30+ year-old drugs?
Deep learning-based microsatellite instability predictor from prostate cancer whole-slide images
Researchers developed a deep learning predictor of MSI in prostate cancer using a large, real-world cohort of H&E whole slide images. The screening algorithm may be used to rapidly prioritize patients for confirmatory testing, which can identify MSI-high patients who may qualify for immunotherapy.
The UK Clinical Eye Research Strategy Unveils New Priorities
The UK Clinical Eye Research Strategy has embarked on a transformative journey to update and refine research priorities in ophthalmology. We delve into the key findings and implications of this groundbreaking initiative, aimed at reshaping the landscape of eye research in the United Kingdom.
The Role of Smartwatch Data in Monitoring Non-Motor Symptoms of Parkinson’s Disease
Accurate and continuous monitoring of symptoms can enable better care and timely intervention. Wearables could facilitate this but are underexplored for monitoring of non-motor symptoms.
Behind the paper: Unraveling the molecular mechanism behind COVID-19 pulmonary pathologies associated with ferroptosis
How we found that ferroptosis is a key driver of lung damage in severe COVID-19 patients,
By Baiyu Qiu, Fereshteh Zandkarimi, Anjali Saqi and Brent R. Stockwell