Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Healthcare & Nursing
Huntingtin’s new interaction site: a tale of DNAJB1 and HTT’s proline-rich domain
by Sara Maria Ayala Mariscal, Josh Vermaas & Janine Kirstein
Cross-species experiments reveal that a less-recognized form of hearing loss may be widespread
Sensory cells in the inner ear interconvert sound vibrations and electrical signals, and neural connections carry the electrical signals to the brain. Hearing loss is thought of as damage to the sensory cells, but our results suggest that damage to neural connections may be more widespread.
Intrinsic suppression of lung innate lymphoid cells by RNA-binding protein, RBM3, through CysLTR1
Cytokine production from lung innate lymphoid cells plays a critical role in inflammatory diseases; however, little is known about how RBPs regulate ILC function. In this paper, we demonstrate the cell-intrinsic effect of RBM3 in dampening the production of type 2 and 17 cytokines in lung ILCs.
A consensus statement for digital surgery
The term ‘digital surgery’ has been widely adopted, though its meaning has not yet been defined. In this study, a panel of 38 global experts within the field of digital surgery reach consensus definition on the term ‘digital surgery’ and define key issues, barriers and future research goals.
Early anesthesia using ketamine may affect addictive behavior later in life
Although anesthesia-induced neurotoxicity has received significant research interest, it is important to note that it was first identified in animals without direct clinical evidence, making it difficult to speculate how this might manifest in children.
Multi-center validation of machine learning model for preoperative prediction of postoperative mortality
This study aimed to create a machine-learning prediction model for 30-day mortality after a non-cardiac surgery that adapts to the manageable amount of clinical information as input features and is validated against multi-centered rather than single-centered data.
Hyperphosphorylated tau polymerizes into amorphous cytotoxic aggregates
One pathological hallmark of Alzheimer’s disease is the accumulation of neurofibrillary tangles that are primarily consisted of hyperphosphorylated tau. Our results highlighted the impact of hyperphosphorylation on tau leading to the spontaneous formation of amorphous cytotoxic aggregates.
