Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
COVID-19's Hidden Toll: Analyzing Changes in Marriage, Divorce, and Birth Rates
Our recent study examines the significant demographic changes in Kerman Province, Iran, during the COVID-19 pandemic, focusing on marriage, divorce, birth, and death rates. Utilizing Poisson regression and interrupted time-series models, we analyzed data spanning from 2017 to 2020.
Time is Precious
Our laboratory has been studying the long noncoding RNA ( lncRNA ) termed FIRRE for over 15 years and yet we have only recently realized we missed something critical: TIME. Time is precious and has changed the way we think about the entire field !
Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage/autophagy pathways
Pectolinarigenin (PEC) from herbal medicine targets DNA topoisomerase II alpha (TOP2A) in bladder cancer (BLCA), causing DNA damage and blocking cell division. It inhibits autophagy, boosting its effectiveness. Combined with gemcitabine, PEC more effectively halts BLCA growth.
Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis
Melatonin may help fight bladder cancer (BLCA) by slowing cancer cell energy production and increasing chemotherapy effectiveness, by targeting ENO1 to enhance gemcitabine’s impact and involving reactive oxygen species and PPARγ regulation. This suggests new methods for improving BLCA treatment.
27.09% Efficiency Silicon Heterojunction Back Contact Solar Cell and Going Beyond
a new generation of heterojunction back contact (HBC) solar cells that not only push efficiency boundaries but also address key challenges in design and implementation.
The Critical Role of Cell Types in Alzheimer’s Disease
Alzheimer’s disease (AD) is widely known for its characteristic features, such as amyloid plaques and neurofibrillary tangles, but the role of different brain cell types in the progression of the disease is becoming increasingly important in research.
The promise in the Sound of a Cough
The image of a world where doctors can diagnose diseases like tuberculosis (TB) simply by listening to the sound of your cough might sound like something from science fiction. Yet, thanks to advances in artificial intelligence (AI) and machine learning, this future is closer than ever before.
Conditional reprogramming: Modeling urological cancer and translation to clinics
Patient-derived conditional reprogramming (CR) lets cells grow indefinitely, aiding in studying cancer, developing treatments, and advancing personalized medicine. This approach shows promise for improving urological cancer treatment.
Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway
Simvastatin, a drug for heart disease by lowering cholesterol, also slows bladder cancer (BLCA) growth. It stops BLCA cells from multiplying by activating PPARγ, a fatty aicd/lipid metabolism pathway. This effect can be reversed with PPARγ inhibitors.
MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3
Our research reveals that MYBL2, a gene-regulating protein, is elevated in bladder cancer (BLCA) and linked to worse patient outcomes. It boosts BLCA growth and spread by activating the CDCA3 gene, working with FOXM1 to enhance cancer traits. This identifies MYBL2 as a key promoter of BLCA.