Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Behind the ALS - How does the protein SOD1 convert between physiological and pathological states?
ALS is a famous neurodegenerative disease. Misfolded SOD1 has been linked to both familial and sporadic ALS. Here, we present a cryo-EM structure of SOD1 fibrils, providing insights into the conversion of SOD1 from its immature form into an aggregated form during pathogenesis of ALS.
Establishing semantic interoperability across cohorts at European level
A prompt response to a pandemic requires data from different sources to be merged and analyzed in the most efficient way. Our work describes how we approached this challenge for COVID-19 data within the European Project ORCHESTRA
Metabolic (dysfunction) associated fatty liver disease in normal weight individuals
There has previously been no rigorous attempt to understand the pathophysiology of MAFLD in healthy weight individuals. This was the aim of our review
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Metabolism across species: using transcriptome profiling to investigate glycolytic and oxidative flux in mammalian embryos
Mammalian embryology research relies on animal models with different developmental timelines and implantation modes. Here, we present a cross-species analysis of 15 single-cell RNA-seq datasets showing conserved glycolysis and oxidative phosphorylation trends in pre-gastrulation mammalian embryos.
In situ electro-synthesis and resynthesis of redox actives in aqueous organic redox flow batteries
We report in situ continuous anthraquinone electrosyntheses from lower-cost anthracene feedstock in a flow cell reactor to lower mass production cost of anthraquinone-based electrolytes, and in situ electro-resyntheses of active molecules from decomposed species to extend lifetime of aqueous anthraquinone redox flow batteries.
