Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Biomedical Research
Mapping the Rise of Indian Orthopaedics: The Story Behind Our Bibliometric Journey
The idea for this paper grew from a simple but pressing question: How far has Indian orthopaedic research really come? As the IJO expanded its visibility and output over nearly two decades, we felt the need for a clear, data-driven map of its growth, strengths, and gaps.
Unveiling the Hidden Inner Architecture of Biomolecular Condensates
The cell's biomolecular condensates harbor nanodomains that trap RNA and proteins, controlling residence time and function; as they age these nanodomains move to the surface, linking internal architecture to fibril formation in neurodegeneration and promise new therapeutic strategies.
Real-time disease monitoring predicts early relapse and refines conventional imaging in patients with DLBCL
Monitoring lymphoma treatment has long relied on PET-CT scans, but these are imperfect. Circulating tumor DNA (ctDNA) offers a minimally invasive, highly specific way to track disease in real time. In our study, we explored how ctDNA can reshape response assessment in DLBCL.
Passing Traits Without Genes: How the Gut Microbiome Transfers Behavior
Microbes can evolve faster than their hosts. We show that selecting only the microbiome, while keeping host genes fixed, can alter mouse behavior across generations. Microbes and their metabolites thus act as agents of adaptation, transmitting traits independently of host DNA.
Modeling t(4;11) leukemia in umbilical cord hematopoietic stem precursor cells
Chromosomal translocations of the KMT2A/MLL gene are frequently diagnosed in acute leukemia patients (ALL and AML) with very poor outcome. Here, we used the CRISPR/Cas9 technology to model this translocation t(4;11)(q21;q23) in hematopoietic stem cells deriving from umbilical cord blood.
Behind the Paper: Navigating the Hidden Hurdles of Science in Ecuador
Scientific progress thrives in the Global North with strong infrastructure and funding, but in the Global South like Ecuador, barriers abound. Our paper highlights non-traditional challenges: power outages , security threats halting fieldwork amid violence, and high import costs for equipment.
From Needles to Pills: The New Era of Weight-Loss Medicine
For years, people struggling with obesity have dreamed of a simple pill that could deliver real, lasting weight loss — without injections, surgery, or extreme diets.
That dream just came much closer to reality..
How Post-Translational Modifications Rewire Cellular Networks Through Epichaperomes
Proteins rarely work alone. Their functions emerge from networks of interactions—dynamic connections that continuously reorganize to maintain cellular balance. But what happens when this balance is lost?
