Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Exploring New Frontiers in Antifungal Therapy: The Essential Role of Vitamin B5 Metabolism
Fungal infections pose a significant global health threat, especially with the alarming rise in drug-resistant strains. Our study, published in Communications Biology, delves into groundbreaking research that could pave the way for novel therapeutic strategies against these pathogens.
De novo atomic protein structure modeling for cryoEM density maps
Cryo2Struct determines atomic structures of large proteins directly from cryo-EM density maps, advancing biomedical research and drug design.
Characterizing amphioxus development at the single-cell level: understanding chordate nervous system development
Our team uncovers new amphioxus central nervous system (CNS) cell types and we highlight three developmental origins for the vertebrate nervous system.
Dysfunctional Protein-Protein Interactome (dfPPI): A Platform for Systems-Level Analysis of PPI Alterations in Disease
Explore Dysfunctional Protein-Protein Interactome (dfPPI): Revealing how aberrant protein interactions drive cancer and neurodegeneration, guiding mechanistic insights and therapeutics innovations.
Structural and functional insights underlying recognition of histidine phosphotransfer protein in fungal phosphorelay systems
Phosphorelay systems found in fungi contain several hybrid histidine kinases that transfer phosphoryl groups to the same His-phosphotransferase. This many-to-one mechanism is promoted through a low affinity for interaction and a transient phosphorylation.
Modeling the Growth and Size Distribution of Human Pluripotent Stem Cell Clusters in Culture
Culturing stem cells for clinical applications requires standardized protocols. Bench-scale experiments with hPSCs result in growth of cell clusters under various culture conditions. Mathematical models of cluster size distributions can help to identify plausible growth laws.
